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KMID : 0363319980190010291
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Journal of Korean Oriental Internal Medicine
1998 Volume.19 No. 1 p.291 ~ p.300
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The latest development in Dementia
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Na Chang-Soo
Kim Jeong-Sang
Chae Woo-Seok
Park Seok-Cheon
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Abstract
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Dementia is the neurodegenerative process that affects cognition, behavior and function and one of the most prominent diseases of dementia is Alzheimer’s disease(AD). AD is a dementing illness characterized clinically by the progressive and irreversible deafferentation of the limbic system, association neocortex and basal forebrain. A number of conditions are known to be predisposing risk factors for AD. In several of these, initiation of glial-mediated inflammatory pathways as a mechanism of AD is getting a lot of attention. On the other hand, a biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. Also such a marker might be used as an end point in clinical intervention protocols. This biochemical marker will have the potential for identifying subjects afflicted with the disease and possibly for monitoring the onset and longitudinal progression of the disease. Here we have reviewed the latest papers of different approaches to AD. Of course, there is a section of PET which is very useful clinically nowadays.
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KEYWORD
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Dementia, Alzheimer’s disease(AD), biochemical marker, PET
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